Resistant Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Analysis of intimal proteoglycans in atherosclerosis-prone and atherosclerosis-resistant human arteries by mass spectrometry.
The propensity to develop atherosclerosis varies markedly among different sites in the human vasculature. To determine a possible cause for such differences in atherosclerosis susceptibility, a proteomics-based approach was used to assess the extracellular proteoglycan core protein composition of intimal hyperplasia from both the atherosclerosis-prone internal carotid artery and the atheroscler...
متن کاملAtherosclerosis Susceptibility Loci Identified in an Extremely Atherosclerosis‐Resistant Mouse Strain
BACKGROUND C3H/HeJ (C3H) mice are extremely resistant to atherosclerosis, especially males. To understand the underlying genetic basis, we performed quantitative trait locus (QTL) analysis on a male F2 (the second generation from an intercross between 2 inbred strains) cohort derived from an intercross between C3H and C57BL/6 (B6) apolipoprotein E-deficient (Apoe(-/-)) mice. METHODS AND RESUL...
متن کاملAtherosclerosis-susceptible and atherosclerosis-resistant pigeon aortic cells express different genes in vivo.
Spontaneous atherosclerosis in the White Carneau (WC-As) pigeon is inherited as a single gene disorder, and its progression closely mirrors the human disease. Representational difference analysis and microarray were used to identify genes that were differentially expressed between the susceptible WC-As and resistant Show Racer (SR-Ar) aortic tissue. The RNA extracted from 1-d-old squab aortas w...
متن کاملGenetic engineering of vein grafts resistant to atherosclerosis.
Previously, researchers have speculated that genetic engineering can improve the long-term function of vascular grafts which are prone to atherosclerosis and occlusion. In this study, we demonstrated that an intraoperative gene therapy approach using antisense oligodeoxynucleotide blockage of medial smooth muscle cell proliferation can prevent the accelerated atherosclerosis that is responsible...
متن کاملAtherosclerosis-Susceptible and Atherosclerosis-Resistant Pigeon Aortic Smooth Muscle Cells Express Different Genes and Proteins in vitro
This review describes theories of human atherogenesis and experimental results evaluating gene or protein expression in the pigeon model for spontaneous atherosclerosis. The spontane‐ ous disease in the pigeon differentiates from other animal models that require manipulation (genetic, nutritional, environmental) to induce the disease state. Both susceptible and resistant pigeons have been studi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stroke
سال: 2017
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.117.017392